CHRC–INSA/ENSP-NOVA Researchers Contributed to New WHO–IARC Monograph on Carcinogenic Agents
Henriqueta Louro, researcher at the Comprehensive Health Research Centre (CHRC) and the National Institute of Health Doctor Ricardo Jorge (INSA), together with Susana Viegas, researcher at NOVA National School of Public Health (ENSP-NOVA) and also affiliated with the CHRC, were part of the international team of experts who contributed to the development of the latest volume of the IARC Monographs on the Identification of Carcinogenic Hazards to Humans (Volume 136), published by the International Agency for Research on Cancer (IARC/WHO).
Volume 136 comprises two monographs dedicated to the agents talc and acrylonitrile. This scientific work aims to assess, based on the most up-to-date evidence, the carcinogenic potential of these compounds, with direct implications for public health and risk prevention policies.
In response to public interest, the monograph on talc was made available in advance on 30 June 2025. The Working Group evaluated talc as probably carcinogenic to humans (Group 2A), based on a combination of limited evidence of cancer in humans, sufficient evidence in experimental animals, and strong mechanistic evidence in human primary cells and experimental systems. This new evaluation supersedes previous classifications for “talc not containing asbestos” and “perineal use of talc-based body powder”. “Talc containing asbestos” was not re-evaluated and remains classified as carcinogenic to humans (Group 1).
Acrylonitrile, a compound widely used in the production of plastics and synthetic fibres, was classified as carcinogenic to humans (Group 1), based on sufficient evidence of cancer in humans and in experimental animals, as well as strong mechanistic evidence showing key characteristics of carcinogens.
The participation of the CHRC researchers reflects the international recognition of Portuguese scientific expertise in the field of toxicology and risk assessment, strengthening the role of the CHRC in advancing translational research in environmental and occupational health.
The full monograph is available on the IARC website: IARC Monographs Volume 136 – Talc and Acrylonitrile